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Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter

Annals Clin Translat Neurol

In addition, recent studies suggest that under certain conditions, such as hyperreduced CoQ pools and elevated mitochondrial membrane potential, reverse electron transport may occurwhereby electrons flow from ubiquinol (CoQ 10 H 2 ) back to complex I, generating NADH 110,111

On the other hand, PTMA due to B12 deficiency is fully reversible with appropriate vitamin replacement therapy